Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA-Gapmer Approach.

Chembiochem · 2020 · PMC7754139 · PMID 32662164

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fairly significantno p-value reported

For hybrid duplexes of NAA‐containing DNA‐ON with RNA, however, a fairly significant loss in thermal stability was observed (Δ T m up to ∼4.0 °C/modification).

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