Cox regression analysis showed a highly significant increase in ongoing mortality risk among patients with an increase in NAC ATTR stage compared with stable NAC ATTR stage {HR 3.19 [95% confidence interval (CI) 1.76–5.77]; P < 0.001}, with consistent results across both genotypes ( Table 3 ).
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Disease progression in cardiac transthyretin amyloidosis is indicated by serial calculation of National Amyloidosis Centre transthyretin amyloidosis stage.
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