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Pharmacodynamic monitoring of factor VIII replacement therapy in hemophilia A: Combining thrombin and plasmin generation.

J Thromb Haemost · 2020 · PMC7756259 · PMID 32979031

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a decreasing trendno p-value reported
In contrast, thrombin potential remained relatively equal to non‐inhibitor patients and did not show a decreasing trend over time.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.