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Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users.

Addict Biol · 2021 · PMC7757162 · PMID 31865628

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an increasing trendno p-value reported
However, because of a changing legal landscape and rising interest in therapeutic utility, there is an increasing trend in (long‐term) use and possibly cannabis impairment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.