Comparison of Trends in Rates of Sexually Transmitted Infections Before vs After Initiation of HIV Preexposure Prophylaxis Among Men Who Have Sex With Men.

JAMA Netw Open · 2020 · PMC7758809 · PMID 33355675

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an increasing trendP < .001actually significant

In the period before PrEP enrollment, there was an increasing trend in quarterly C trachomatis or N gonorrhoea positivity (RR increase, 1.08 per quarter [or an 8% increase per quarter]; 95% CI, 1.05-1.11 per quarter; P < .001); however, no trend was observed after starting PrEP (RR increase, 1.01 per quarter; 95% CI, 0.99-1.02 per quarter; P = .29).

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