Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer's Disease.

Although the model gave relatively high R 2 (cum) and Q 2 (cum) values (0.997 and 0.842, respectively), p [CV-ANOVA] was calculated to be 0.05442, suggesting that the group separation for the midbrain matrix may not be significant.

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Tg2576 transgenic mice treated with low-dose PIO nanoparticles over four months exhibited an overall trend of reduced hyperactivity in open field tests but did not show any visible effect on alternation rates in the Y-maze task.

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