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Current Evidence of Interleukin-6 Signaling Inhibitors in Patients With COVID-19: A Systematic Review and Meta-Analysis.

Front Pharmacol · 2020 · PMC7769953 · PMID 33384605

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an evident trendno p-value reported
By contrast, in patients with critical disease, the beneficial effect of anti-IL-6/IL-6R/JAK antibodies on mortality became indistinct, and resulted in an evident trend of increased secondary infection rates.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.