a nonsignificant trendP < 0.10
A nonsignificant trend ( P < 0.10) of caffeine use was observed for alcohol user.[ 17 ] The review of studies demonstrated that high caffeine intake was associated with psychotic and manic symptoms or exacerbation of previous psychotic symptoms.[ 18 ] Research suggested that excessive caffeine intake might hamper the recovery of patients with bipolar disorder or manic-type mood episodes.