The prognostic significance of the treatment response of regional lymph nodes and the refinement of the current TNM staging system in locally advanced rectal cancer after neoadjuvant chemoradiotherapy.

3.4 Survival estimates according to LRGmax, LRGsum, and LRG ratio The DFS difference was highly significant ( p < 0.001), as were the differences between the groups of LRGmax 0–1 and LRGmax 2–3 ( p < 0.001), the groups of LRGmax 0–1 and LRGmax 4–5 ( p < 0.001) and the groups of LRGmax 2–3 and LRGmax 4–5 ( p = 0.002, Table 2 , Figure 3A ).

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