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Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis.

PLoS One · 2020 · PMC7774834 · PMID 33382782

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an increasing trendno p-value reported
[ 99 ] demonstrated an increasing trend in IL-6 protein production in mouse skin and embryonic fibroblasts at 8h (IT) after challenge with IL-1.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.