Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling.

Nonetheless, this increase was modest with TRPC6 expression ( Figure 3A ) and repetitive, transient activation of the TRPC6 conductance by light resulted in a robust and highly significant NFAT1 nuclear translocation ( Figure 3 and Supplementary Video 1 ).

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