Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity.

Sci Adv · 2021 · PMC7775773 · PMID 33523837

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantP = 6.10 × 10 −5actually significant

However, after controlling for the single-gene effect, the partial correlation between TCL and cancer risk is still highly significant (Spearman’s ρ = −0.69, P = 6.10 × 10 −5 ; fig.

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borderline significantP = 0.06so close (0.05 < p ≤ 0.1)

LADM and NSCD are significantly correlated (Spearman’s ρ = 0.66, P = 0.02), while the TCL correlates only in a borderline significant manner with either NSCD (Spearman’s ρ = −0.57, P = 0.06) or LADM (Spearman’s ρ = −0.52, P = 0.08).

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