Heterozygous germline <i>BLM</i> mutations increase susceptibility to asbestos and mesothelioma.

S1 D ), a highly significant incidence ( P = 6.7E-10) compared to the expected frequency of pathogenic BLM mutations in the general population of 1 in 900 ( 25 ), and as high as the 1-in-100 incidence among people of Ashkenazi Jewish ancestry, who carry a specific set of mutations ( 29 ) that were not found in any of our patients, as none of them were of Ashkenazi Jewish ancestry.

also in 132,142 other papers