Obesity has been proposed to be a highly significant risk factor for breast carcinogenesis, cancer progression, and aggressiveness ( 3 ), as excessive adipose tissue in obese patients not only alters the local microenvironment by remodeling extracellular matrix (ECM) but also provides both energy and niches for cancer cell proliferation, metastasis, and avoidance of chemotherapy ( 4 , 5 ).
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Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin.
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