Osteoblasts derived from mouse mandible enhance tumor growth of prostate cancer more than osteoblasts derived from long bone.

MaOB seeded ossicles appeared larger in area than HLOB ossicles, although not quite significant ( Fig. 8 F), but contained a significantly greater number of total and proliferating cells, as evidenced by Ki67 nuclear positivity ( Fig. 8 G&H). 4 Discussion In this study, we first demonstrated that in the intracardiac model of metastatic PCa, mandible bone lesions often occur before hind limb bone lesions, which is anecdotally well-recognized.

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