Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages.

As for the virus containing the functional integrase (Fig 2A–C ), the colocalization of vDNA and vRNA was highly significant and intensities in colocalizing clusters correlated significantly (Spearman’s r = 0.51, P = 1.6 × 10 −5 ) (Fig 4B and C ).

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