Variants in <i>PPP2R2B</i> and <i>IGF2BP3</i> are associated with higher tau deposition.

Brain Commun · 2020 · PMC7780444 · PMID 33426524

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0.0600

closest p · 1.2× alpha

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boldest claim

The sentences

marginally nonsignificantP = 0.06so close (0.05 < p ≤ 0.1)

In addition to these discoveries, three single nucleotide polymorphisms within MAPT (microtubule-associated protein tau) displayed nominal associations with tau-positron emission tomography burden, and the association of the APOE (apolipoprotein E) ɛ4 allele with tau-positron emission tomography was marginally nonsignificant ( P = 0.06, β = 0.07).

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marginally significantno p-value reported

Overall, carriers of rs76752255-C were significantly more impaired than non-carriers based on the Clinical Dementia Rating scale ( P < 0.001) despite having no or marginally significant differences in age, sex, education, cerebrovascular disease risk and brain amyloid burden ( Supplementary Table 3 ).

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