The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.

Cd4 − Cd8a + selection intermediates expressed slightly less Cd69, Egr1 and Itm2a , (but not Nr4a1 ) than Cd4 + Cd8a − selection intermediates, but differences in TCR signalling gene expression between subsets of selection intermediates were minor compared to the highly significant changes from pre-selection DP to selection intermediates (Fig. 3a ).

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MHC class II −/− selection intermediates showed a notable trend for increased expression of the IL7R downstream gene Gimap3 as well as Runx1 and Runx3 as potential mediators of coreceptor switching from Cd4 + Cd8a − to Cd4 − Cd8a + (refs. 4 , 20 , 22 ).

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