Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.

3a, two-way analysis of variance (TWA) indicates that the influence of age is highly significant but only explains ~7% of the Rres changes when compared with either substrate (Supplementary Fig. 3a ) or strain (Supplementary Fig. 3b ).

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In contrast, HCR cardiomyocytes exhibit significantly higher Rres than LCR in the presence of Palm or Gluc + Palm, across the ages, except in Palm at 24 months where a nonsignificant trend was observed.

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