Previous pharmacological studies have found children are less likely to tolerate and/or respond to SSRIs with increased risk of adverse effects [ 64 , 65 ], suggesting that there might be significant differences in brain 5-HT function in pre- and post-pubertal individuals with ASD [ 66 ].
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Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial.
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