The functional outcomes of this property were highly significant, since as few as 25,000 mobilized MPP cells adoptively transferred per recipient conferred protection against EAE, and this protection was highly dependent on Treg as demonstrated by disease relapse upon Treg depletion by the PC61 mAb treatment in MPP-recipient mice.
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Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis.
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