Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis and poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets.

J Neurovirol · 2021 · PMC7786889 · PMID 33405206

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may not be significantno p-value reported

Yet, PARP1 resulted neither over or under expressed in animals with SIV infection in the frontal cortex, suggesting that its contribution to neuroAIDS may not be significant, despite its known role in HIV suppression by regulating HIV infection and integration (Ha et al. 2001 ; Kameoka et al. 2004 ).

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