Plasma levels of norepinephrine and expression levels of ß2-adrenergic receptor gene correlate with the incidence of acute graft-versus-host disease.

The plasma levels of norepinephrine in Non-aGvHD patients showed a steady-state trend with the mean rang of about 620 to 680 pg/mL while patients who developed aGvHD had a decreasing trend in which the mean plasma levels at day +21 (≈155 pg/mL) were significantly lower than those of day -7 and day 0 (≈455 pg/mL) ( Fig. 1 C ).

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