Differentiating axonal loss and demyelination in chronic MS lesions: A novel approach using single streamline diffusivity analysis.

In concordance with these findings, we observed a highly significant correlation of ΔAD (but not ΔRD) between the lesion core and the extra-lesional part of the lesional fibers and a preferential increase of AD in lesional fibers outside the lesion in the current study, supporting ΔAD as a potential biomarker of WD, even outside of highly coherent fiber tracts.

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