Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA.

PLoS Pathog · 2020 · PMC7787678 · PMID 33351861

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hedged sentence

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closest p · 0.0× alpha

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boldest claim

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highly significantp<0.0001actually significant

We observed a highly significant decrease in global viral mRNA levels from proviruses formed by the acetylation deficient QA mutant IN (20-fold, p<0.0001).

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