The STM and LTM probe tests that were carried out to assess spatial memory showed a significant main effect of genotype, almost significant main effect of probe test, and a significant genotype by age by probe test (Fig. 5 d–g; genotype: F (1, 1686) = 44.9, p < 0.0001; probe test: F (1, 154) = 4.11, p =0.0502; genotype by age by probe day: F (1, 357) = 9.51, p =0.00391).
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Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits.
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