highly significantp ≤ 0.001
In both PC-3 and HCT-116 models, there was significantly increased caspase 3/7 activity in the PTEN-deficient cells when compared to PTEN expressing cells 48 h following KU-60019 ( p ≤ 0.05; p ≤ 0.05) or IR ( p ≤ 0.05; p ≤ 0.05) and a highly significant increase following combined KU-60019 + IR treatment ( p ≤ 0.001; p ≤ 0.01). 2.4.