Whilst mTOR inhibition would also be consistent with certain eIF4F complex components including eIF4G decreasing in association ( Supplementary Figure S1A ), within the RNA interactome capture data we observed eIF4G showing a decrease in binding following mTOR inhibition, however this failed to reach significance ( Supplementary Table S1 ).
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The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
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