SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci.

Thus, the hot-spot mutations in SARS-CoV-2 were enriched within IRs loci and this association was highly significant statistically ( P -value = 0.0001085; t = −5.94, df = 9, one-sample t -test) ( Figure 1 ).

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