Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma.

Oncoimmunology · 2021 · PMC7801125 · PMID 33489468

Europe PMC DOI

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0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

a trend toward significancep = .09so close (0.05 < p ≤ 0.1)

Compared to isotype controls, a large increase in survival was observed for mice with established tumors receiving anti-PD-1 monotherapy ( p < .005) or anti-PD-1 plus anti-CTLA-4 together ( p < .0005) when administered after chemotherapy, and a trend toward significance was observed between these two groups ( p = .09) ( Figure 3E,F , Figure S6).

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