Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity.

The terms clustered semantically along the X -axis based on the similarity: highly significant terms ( p < 0.001) including “actin cytoskeleton organization” and “fiber polymerization,” clustered on the left, progressed to “response to mechanical stimuli” and terminated on the right with signaling pathways, including G-protein coupled receptors (GPCR), regulation of interleukin-8 (CXCL8) production, and Rho protein signal transduction (Fig. 4e , Supplementary Fig. 3b ).

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