Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to <i>Schistosoma mansoni</i>: Structural and Mechanistic Insights into Chemotype Reactivity.

The correlation between the severity scores generated by the azanitriles against the parasite and their potency of inhibition of SmCB1 was highly significant ( Table S3 , Spearman correlation test with nonzero value coefficients, 20 000 permutations, p < 0.001).

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