A novel dietary multi-strain yeast fraction modulates intestinal toll-like-receptor signalling and mucosal responses of rainbow trout (Oncorhynchus mykiss).

PLoS One · 2021 · PMC7802930 · PMID 33434201

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highly significantno p-value reported

In particular, the results indicate a highly significant elevation in irak4 (>2 fold increase), which is central to the TIR domain and subsequent TLR signalling cascade.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.