Impact of <i>RAS/RAF</i> mutations on clinical and prognostic outcomes in metastatic colorectal cancer.

2 Despite the long-standing screening and early detection programs as well as improvements in cancer treatment and management using targeted therapies in most developed countries, its incidence and mortality have shown an increasing trend in some regions of the world, especially Asia and developing countries. 1 , 3 , 4 CRC represents a heterogeneous genetic and epigenetic alteration that could lead to different phenotypes.

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