Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling.

Epigenetics Chromatin · 2021 · PMC7805211 · PMID 33436083

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highly significantp = 2.72E-21actually significant

Two highly significant DMRs (DMR1 p = 2.72E-21; DMR2 p = 1.84E-08) were discovered within the primary and alternative promotors and leading exons of the MAP2K3 gene that encodes the MAP kinase kinase, MKK3 (Fig. 4 b).

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