Despite an assumption of “small” fluctuations used to justify the linear mass-action kinetics of Eq [ 2 ] , we found an increasing trend of mutual information for longer daisy chains simulated using the SSA for 2 to 128 source molecules [ 13 ], in qualitative agreement with predictions based on the rate equation approach.
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Devil in the details: Mechanistic variations impact information transfer across models of transcriptional cascades.
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