Assessing the applicability of the new Global Lung Function Initiative reference values for the diffusing capacity of the lung for carbon monoxide in a large population set.

Multiple linear regression analysis showed, in both genders, a highly significant relationship between z-scores differences (ECSC vs GLI-2017) and age (as in the “control” group) (p < 0.0001, in both genders), the decrease in D LCO severity (p < 0.0001, in both genders) and the interaction between age and severity (p < 0.0001 in both genders).

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