Erythropoietin reduces fat mass in female mice lacking estrogen receptor alpha.

EPO treatment for 2 weeks in the obese ERα adipoKO mice but not the WT mice decreased the expression of these WAT-associated genes, Ednra, Psat1, resistin, and Wdnm1-like, with a decreasing trend in Serpina3k expression ( Figure 7 A).

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Leptin receptor mRNA levels showed an increasing trend with EPO treatment in the female WT and ERα−/− mice on the HFD, respectively ( Figure 3 H).

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