Interleukin 6, soluble interleukin 2 receptor alpha (CD25), monocyte colony-stimulating factor, and hepatocyte growth factor linked with systemic hyperinflammation, innate immunity hyperactivation, and organ damage in COVID-19 pneumonia.

Cytokine · 2021 · PMC7810025 · PMID 33493861

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highly significantno p-value reported

ROC curve analyses for IL-6 (AUC 0.83, 95% CI 0.73–0.93, P < 0.0001), M-CSF (AUC 0.87, 95% CI 0.79–0.96, P < 0.0001), HGF (AUC 0.81, 95% CI 0.70–0.93, P < 0.0001), and sIL-2Rα (AUC 0.80, 95% CI, 0.69–0.90, P < 0.0001) showed that these four soluble factors were highly significant.

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