Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration.

On the other hand, expression of SQSTM1 or protein 62 (p62) was elevated both in the 3-NPA and MPP + models, with an increasing trend in Mn in the total extract (Fig. 4 I,J; corresponding full blot in supplementary Figure 10 i), which was also reflected in the soluble fraction (Supplementary Figure 10 ii).

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