Reduced RNA turnover as a driver of cellular senescence.

Life Sci Alliance · 2021 · PMC7812316 · PMID 33446491

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Gene Ontology (GO) term analysis of genes up-regulated upon Exosc3 inactivation further revealed a highly significant enrichment in genes associated with the p53 pathway and we noted increased expression of the senescence markers Cdkn2b/p15 , Cdkn2a/p16 , and Cdkn1a/p21 ( Fig 5I and J and Table S2 listing differentially regulated genes associated with the GO terms).

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