Barely Significant
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Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein.

Proc Natl Acad Sci U S A · 2021 · PMC7812859 · PMID 33361333

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highly significantno p-value reported
The YIDI motif is responsible for stabilizing an extensive noncovalent dimer interface in the crystal, scored as highly significant ( 19 ) on the basis of its 1,700 Å 2 of buried surface area and hydrophobicity.

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