One of these is that environmental pathogens trigger inflammation, drive inflammatory cells into alveolar and interstitial spaces, and cause possibly significant damage to the alveolar epithelium. 2 , 3 This may explain why patients with SSc show higher serum levels of surfactant protein D and Krebs von den Lungen-6, two glycoproteins expressed by type II alveolar cells and used as biomarkers of pulmonary epithelium damage. 4 It is likely that the entity of
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Efficacy of cyclophosphamide in treating connective tissue disease-related interstitial lung diseases.
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