Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999-2017.

The proportion of IVIG non-responders showed a decreasing trend in autumn and that of IVIG responders showed an increasing trend over autumn to winter. 29 In this cohort, the seasonality of IVIG non-responders tended to differ by sex; the proportions of female IVIG non-responders tended to increase during summer, whereas those of their male counterparts tended to decrease in autumn. 29 Those responses to IVIG therapy may reflect the etiological agents of KD and/or immune reactivity against such agents, which possibly differ by sex.

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While the overall proportion of patients with CAAs were significantly lower in summer than in other seasons, the proportion of patients with giant aneurysms showed an increasing trend in autumn, with nadir incidence of KD occurrence.

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