Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling.

First of all, qPCR analysis on total cortical RNA samples showed highly significant increase on N1ICD mRNA levels in Pen‐2 cKO mice expressing NICD compared with Pen‐2 cKOs without NICD expression (Figure 5B ).

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