Universal and taxon-specific trends in protein sequences as a function of age.

This is because there is no more than marginal significance for correlations between phylostratigraphy slope and the metabolic cost of amino acid production in yeast ( Figure 4—figure supplement 2 ; amino acids are color-coded by costliness in Figure 4 ; Raiford et al., 2008 ).

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While the error bars are larger, the trend remains highly significant for ancient domains (see Figure 5—figure supplement 2), not barely so as the reviewer states.

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