RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia.

Functional annotation by DAVID uncovered a highly significant enrichment of RUNX1/RUNX1T1 binding at gene loci that are subject to alternative splicing and splice variants (false discovery rate adjusted p -value or q -value, 4.0 × 10 −23 and 1.5 × 10 −12 , respectively; Supplementary Fig. 1a , Supplementary Data 2 ) 24 .

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