The results of the present study point to renal endoplasmic reticulum stress as a highly significant mechanism that triggers the three main alterations that lead to kidney disfunction and injury, i.e., (1) mitochondrial dysfunction and reduced fatty acid oxidation, (2) unrestrained autophagia and (3) augmented SREBP-1 activity, increasing fatty acid synthesis.
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The Role of the Unfolded Protein Response on Renal Lipogenesis in C57BL/6 Mice.
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