Altered Spatial Composition of the Immune Cell Repertoire in Association to CD34⁺ Blasts in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia.

However, MSI demonstrated a complete absence of CD8 + and FOXP3 + T cells within a radius of 10 μm and a highly significant lower frequency of MUM1p + CD3 − B/plasma cells within a radius of <50 μm to CD34 + HSPC in control samples, while in MDS/sAML BMB, these cells were regularly detected in these localizations.

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