The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosa.

Mol Biol Evol · 2021 · PMC7826179 · PMID 32931584

Europe PMC DOI

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a statistical trendP < 0.1so close (0.05 < p ≤ 0.1)

Three other monotherapies (STR, IMI, and DOR) and the CEF+DOR combination showed a statistical trend ( P < 0.1) toward lower relative growth rates ( supplementary table S3 , Supplementary Material online), possibly indicating that some monotherapies more often lead to an evolutionary trade-off than drug combinations.

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